Computational Nuclear Oncology for Precision Radiopharmaceutical Therapies: Towards Theranostic Digital Twinning of Cancer Patients

Forum Details

Date: May 16, 2025 12-1 PM Eastern time

Speakers: Arman Rahmim, PhD

The world of radiation therapy is currently undergoing a major renaissance, involving theranostics and radiopharmaceutical therapies (RPTs) with very impressive results in cancer patients. Theranostics involves using matched pairs of radiolabeled molecules for imaging and therapy using the same cell targets. The emerging theranostics paradigm allows us to “see what we treat and treat what we see” in cancer patients. However, full potentials of theranostics remains underexplored. Beyond seeing what is treated, there is a need to quantify disease, predict responses to therapy, and personalize RPTs. Currently, RPTs are performed with a “one size fits all” approach in which every patient is injected with the same amount of radioactivity per cycle, not accounting for inter-patient variations. In this talk, we outline our vision of and efforts towards realization of theranostic digital twins (TDTs) to enable predictive dosimetry and personalization of therapies, delivering maximum radiation doses to tumors while sparing organs-at-risk.